Publications

 • Miles R. Bryan III, Xu Tian, Jui-Heng Tseng, Baggio A. Evangelista, Joey V. Ragusa, Audra F. Bryan, Winifred Trotman, David Irwin, Todd J. Cohen. Development and characterization of novel anti-acetylated tau monoclonal antibodies to probe pathogenic tau species in Alzheimer's disease. Acta Neuropathologica Communications. 2024; Oct 12; 12(1): 163.

 • Jui-Heng Tseng, Todd J. Cohen. The emerging nontraditional roles for tau in the brain. Cytoskeleton. 2023; Dec 8. Online ahead of print.

 • Zarin Tabassum‡, Jui-Heng Tseng‡, Camryn Isemann, Xu Tian, Youjun Chen, Laura E. Herring, Todd J. Cohen. Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase. Journal of Biological Chemistry. 2022; 101977.

 • Ivana Y. Quiroga, Aimee E. Cruikshank, Kathleen S. M. Reed, Marielle L Bond, Baggio A Evangelista, Jui-Heng Tseng, Joey V Ragusa, Rick B. Meeker, Hyejung Won, Sarah Cohen, Todd J. Cohen, Douglas H. Phanstiel. Synthetic amyloid beta does not induce a robust transcriptional response in innate immune cell culture systems. Journal of Neuroinflammation. 2022; 19 (1): 1-12. 

• Jui-Heng Tseng, Aditi Ajit, Zarin Tabassum, Niyati Patel, Xu Tian, Youjun Chen, Alex W. Prevatte, Karen Ling, Frank Rigo, Rick B. Meeker, Laura Herring, Todd J. Cohen. Tau seeds are subject to aberrant modifications resulting in distinct signatures. Cell Reports. 2021; 35 (4), 109037.

• Jie Gao, Chen Suo, Jui-Heng Tseng, Melissa A. Moss, Alvin V. Terry Jr., James Chapman. Design and synthesis of ranitidine analogs as multi-target directed ligands for the treatment of Alzheimer’s disease. International Journal of Molecular Sciences. 2021; 22 (6), 3120.

• Hanna Trzeciakiewicz, Deepa Ajit, Jui-Heng Tseng, Youjun Chen, Aditi Ajit, Zarin Tabassum, Rebecca Lobrovich, Claire Peterson, Michelle S Itano, Natallia V. Riddick, Ashutosh Tripathy, Sheryl Moy, Virginia M.Y. Lee, John Q. Trojanowski, David J. Irwin, Todd J. Cohen. An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline. Nature Communications. 2020; 11 (1), 1-18.

• Connor M. Wander, Jui-Heng Tseng, Sheng Song, Heba Al Housseiny, Seth Tart, Aditi Ajit, Yen- Yu Ian Shih, Rebecca Lobrovich, Juan Song, Rick B. Meeker, David J. Irwin, Todd J. Cohen. The accumulation of tau-immunoreactive hippocampal granules and corpora amylacea implicates reactive glia in tau during aging. iScience. 2020; 23 (7), 101255

• Deepa Ajit, Hanna Trzeciakiewicz, Jui-Heng Tseng, Connor M. Wander, Youjun Chen, Aditi Ajit, Diamond P. King, Todd J. Cohen. A unique tau conformation generated by an acetylation-mimic mutation modulates P301S-dependent tau pathology and hyper-phosphorylation. Journal of Biological Chemistry. 2019; 294 (45), 16698-16711

• Jui-Heng Tseng, Ling Xie, Sheng Song, Youmei Xie, Lauren Allen, Deepa Ajit, Jau-Shyong Hong, Xian Chen, Rick B. Meeker, Todd J. Cohen. The deacetylase HDAC6 mediates endogenous neuritic tau pathology. Cell Reports. 2017; 20 (9), 2169-2183

• Hanna Trzeciakiewicz, Jui-Heng Tseng, Connor M. Wander, Victoria Madden, Ashutosh Tripathy, Chao-Xing Yuan, Todd J. Cohen. A dual pathogenic mechanism links tau acetylation to sporadic tauopathy. Scientific Reports. 2017; 7 (1), 1-13

‡ These authors contributed equally to this work